Mixed oxide fuel, commonly referred to as MOX fuel, is nuclear fuel that contains more than one oxide of fissile material, usually consisting of plutonium blended with natural uranium, reprocessed uranium, or depleted uranium. MOX fuel is an alternative to the low-enriched uranium (LEU) fuel used in the light-water reactors that predominate nuclear power generation.

For example, a mixture of 7% plutonium and 93% natural uranium reacts similarly, although not identically, to LEU fuel (3 to 5% uranium-235). MOX usually consists of two phases, UO₂ and PuO₂, and/or a single phase solid solution (U,Pu)O₂. The content of PuO₂ may vary from 1.5 wt.% to 25–30 wt.% depending on the type of nuclear reactor.

One attraction of MOX fuel is that it is a way of utilizing surplus weapons-grade plutonium, an alternative to storage of surplus plutonium, which would need to be secured against the risk of theft for use in nuclear weapons. On the other hand, some studies warned that normalising the global commercial use of MOX fuel and the associated expansion of nuclear reprocessing will increase, rather than reduce, the risk of nuclear proliferation, by encouraging increased separation of plutonium from spent fuel in the civil nuclear fuel cycle.